Comment on "Ym1/2 promotes Th2 cytokine expression by inhibiting 12/15(S)-lipoxygenase: identification of a novel pathway for regulating allergic inflammation".
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چکیده
On the cover: Dynamic change of the localization of FROUNT and CCR5 in CCL4-stimulated cell. Immunofluorescent staining at 20 min after stimulation detects colocalization of FROUNT (red) and CCR5 (green) in both the pseudopodial area and the inner cellular space (colocalization is white). Toda, E., Y. Terashima, T. Sato, K. Hirose, S. Kanegasaki, and K. Matsushima. 2009. FROUNT is a common regulator of CCR2 and CCR5 signaling to control directional migration. J. Immunol. 183: 6387–6394.
منابع مشابه
Ym1/2 promotes Th2 cytokine expression by inhibiting 12/15(S)-lipoxygenase: identification of a novel pathway for regulating allergic inflammation.
The Ym1/2 lectin is expressed abundantly in the allergic mouse lung in an IL-13-dependent manner. However, the role of Ym1/2 in the development of allergic airways disease is largely unknown. In this investigation, we show that treatment of mice with anti-Ym1/2 Ab during induction of allergic airways disease attenuated mediastinal lymph node production of IL-5 and IL-13. Ym1/2 was found to be e...
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متن کامل12/15-Lipoxygenase Is an Interleukin-13 and Interferon-γ Counterregulated-Mediator of Allergic Airway Inflammation
Interleukin-13 and interferon-γ are important effectors of T-helper cells. Interleukin-13 increases expression of the arachidonic acid-metabolizing enzyme, 15-lipoxygenase-1, in a variety of cell types. 15-lipoxygenase-1 is dramatically elevated in the airways of subjects with asthma. Studies in animals indicate that 15-lipoxygenase-1 contributes to the development of allergic airway inflammati...
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ورودعنوان ژورنال:
- Journal of immunology
دوره 183 10 شماره
صفحات -
تاریخ انتشار 2009